Infectious Causation of Parkinsonism: A Review

Objective: Review was done to study how H. Pylori contributes to idiopathic Parkinsonism was discovered. Method: I searched the electronic databases for studies related to Prevalence of H pylori in Parkinson’s disease (Epidemiological studies and recruitment figures for clinical trial) and H. Pylori eradication in Parkinson’s disease Randomised controlled trials and clinical controlled trials (nonrandomised). Finding: Prevalence of H. Pylori in Parkinsonism patient varied. The case control studies were conducted by many authors. Taking controls as siblings and assessed exposure by seropositivity of the cases for H Pylori. Two studies observed cohort effect in seropositivity of H. Pylori in PD. Studies done in mice reported increase in motor symptoms in mice infected with H. Pylori, similar to Parkinson. Randomised controlled trials have shown increased improvement in motor symptoms of Parkinson after eradication therapy of H. Pylori. One clinical trial also reported the same. Conclusion: By series of study design in temporal progression it lead to discovery that H. Pylori plays a role in causation of Parkinsonism.